By AAMER MADHANI, Associated Press

WASHINGTON (AP) — President Donald Trump said Saturday that the U.S. military struck three sites in Iran, directly joining Israel ’s effort to decapitate the country’s nuclear program in a risky gambit to weaken a longtime foe amid Tehran’s threat of reprisals that could spark a wider regional conflict.

The decision to directly involve the U.S. comes after more than a week of strikes by Israel on Iran that have moved to systematically eradicate the country’s air defenses and offensive missile capabilities, while damaging its nuclear enrichment facilities. But U.S. and Israeli officials have said that American stealth bombers and a 30,000-lb. bunker buster bomb they alone can carry offered the best chance of destroying heavily-fortified sites connected to the Iranian nuclear program buried deep underground.

“We have completed our very successful attack on the three Nuclear sites in Iran, including Fordow, Natanz, and Esfahan,” Trump said in a post on social media. “All planes are now outside of Iran air space. A full payload of BOMBS was dropped on the primary site, Fordow. All planes are safely on their way home.”

The strikes are a perilous decision for the U.S. as Iran has pledged to retaliate if it joined the Israeli assault, and for Trump personally, having won the White House on the promise of keeping America out of costly foreign conflicts and scoffed at the value of American interventionism.

THIS IS A BREAKING NEWS UPDATE. AP’s earlier story follows below.

TEL AVIV, Israel (AP) — Israel ‘s military said Saturday it was preparing for the possibility of a lengthy war, while Iran’s foreign minister warned that U.S. military involvement “would be very, very dangerous for everyone.”

The prospect of a wider war threatened, too. Iranian-backed Houthi rebels in Yemen said they would resume attacks on U.S. vessels in the Red Sea if the Trump administration joins Israel’s military campaign. The Houthis paused such attacks in May under a deal with the U.S.

The U.S. ambassador to Israel announced the U.S. has begun “assisted departure flights,” the first from Israel since the Hamas-led attack on Oct. 7, 2023, that sparked the war in Gaza.

Hamas has been designated as a terrorist organization by the United States, Canada and the European Union.

Israel’s military said it struck an Iranian nuclear research facility overnight and killed three senior Iranian commanders in pursuit of its goal to destroy Iran’s nuclear program. Smoke rose near a mountain in Isfahan, where the province’s deputy governor for security affairs, Akbar Salehi, confirmed Israeli strikes damaged the facility.

The target was a centrifuge production site, Israel’s military said. The International Atomic Energy Agency confirmed the attack and said the facility — also targeted in the war’s first day — was “extensively damaged,” but that there was no risk of off-site contamination.

Iran again launched drones and missiles at Israel but there were no reports of significant damage. An Israeli military official, speaking on condition of anonymity under army guidelines, estimated the military has taken out more than 50% of Iran’s launchers.

“We’re making it harder for them to fire toward Israel,” he said.

The Israeli military’s chief spokesman, Brig. Gen. Effie Defrin, later said Chief of Staff Lt. Gen. Eyal Zamir told the army to prepare for a “prolonged campaign.”

US aerial refueling tankers on the move

U.S. President Donald Trump is weighing active U.S. military involvement in the war, and was set to meet with his national security team Saturday evening. He has said he would put off his decision for up to two weeks.

Iranian Foreign Minister Abbas Araghchi said U.S. military involvement “would be very, very dangerous for everyone.” He spoke on the sidelines of an Organization of Islamic Cooperation meeting in Turkey. Araghchi was open to further dialogue but emphasized that Iran had no interest in negotiating with the U.S. while Israel continues to attack.

Barring a commando raid or even a nuclear strike, Iran’s underground Fordo uranium enrichment facility is considered out of reach to all but America’s “bunker-buster” bombs. The U.S. has only configured and programmed its B-2 Spirit stealth bomber to deliver the bomb, according to the Air Force.

On Saturday, multiple U.S. aerial refueling tankers were spotted on commercial flight trackers flying patterns consistent with escorting aircraft from the central U.S. to the Pacific. B-2 bombers are based in Missouri. It was not clear whether the aircraft were a show of force or prepared for an operation. The White House and Pentagon did not respond to requests for comment.

The war’s toll

The war erupted June 13, with Israeli airstrikes targeting Iran’s nuclear and military sites, top generals and nuclear scientists. At least 722 people, including 285 civilians, have been killed in Iran and more than 2,500 wounded, according to a Washington-based Iranian human rights group.

One Tehran resident, Nasrin, writhed in her hospital bed as she described how a blast threw her against her apartment wall. “I’ve had five surgeries. I think I have nothing right here that is intact,” she said Saturday. Another patient, Shahram Nourmohammadi, said he had been making deliveries when “something blew up right in front of me.”

Several Iranians have fled the country. “Everyone is leaving Tehran right now,” said one who did not give his name after crossing into Armenia.

For many Iranians, it is difficult to know what’s going on. Internet-access advocacy group NetBlocks.org said Saturday that limited internet access had again “collapsed.” A nationwide internet shutdown has lasted for several days.

Iran has retaliated by firing more than 450 missiles and 1,000 drones at Israel, according to Israeli army estimates. Israel’s multitiered air defenses have shot down most of them, but at least 24 people in Israel have been killed and over 1,000 wounded.

No date has been set for more talks after negotiations in Geneva failed to produce a breakthrough Friday.

Iran’s nuclear program

Iran has long maintained its nuclear program is for peaceful purposes, but it is the only non-nuclear-weapon state to enrich uranium up to 60% — a short, technical step away from weapons-grade levels of 90%. Israel is widely believed to be the only Middle Eastern country with a nuclear weapons program but has never acknowledged it.

Israeli Prime Minister Benjamin Netanyahu has said Israel’s military operation will continue “for as long as it takes” to eliminate what he called the existential threat of Iran’s nuclear program and ballistic missile arsenal.

Iranian President Masoud Pezeshkian said Saturday that his country will never renounce its right to nuclear power, which “cannot be taken away from it through war and threats.” Pezeshkian told French President Emmanuel Macron via phone that Iran is ready to provide guarantees and confidence-building measures to demonstrate the peaceful nature of its nuclear activities, according to IRNA, the state-run news agency.

Iran previously agreed to limit its uranium enrichment and allow international inspectors access to its nuclear sites under a 2015 deal in exchange for sanctions relief. But after Trump pulled the U.S. out of the deal during his first term, Iran began enriching uranium up to 60% and restricting access to its nuclear facilities.

Iran has insisted on its right to enrich uranium — at lower levels — in recent talks over its nuclear program. But Trump, like Israel, has demanded Iran end its enrichment program altogether.

Attacks on Iranian military commanders

Israel’s defense minister said the military killed a paramilitary Revolutionary Guard commander who financed and armed Hamas in preparation for the Oct. 7 attack on Israel.

Iranian officials did not immediately confirm Saeed Izadi’s death, but the Qom governor’s office said a four-story apartment building was hit and local media reported two people had been killed.

Israel also said it killed the commander of the Quds Force’s weapons transfer unit, who it said was responsible for providing weapons to Hezbollah and Hamas. Behnam Shahriyari was killed while traveling in western Iran, the military said.

Iran threatens head of UN nuclear watchdog

Iranian leaders say IAEA chief Rafael Grossi’s statements about the status of Iran’s nuclear program prompted Israel’s attack. On Saturday, a senior adviser for Iran’s Supreme Leader Ali Khamanei, Ali Larijani, said on social media, without elaboration, that Iran would make Grossi “pay” once the war is over.

Grossi on Friday warned against attacks on Iran’s nuclear reactors, particularly its only commercial nuclear power plant in the southern city of Bushehr. A direct hit “would result in a very high release of radioactivity,” Grossi said, adding: “This is the nuclear site in Iran where the consequences could be most serious.”

Israel has not targeted Iran’s nuclear reactors, instead focusing on the main uranium enrichment facility at Natanz, centrifuge workshops near Tehran, laboratories in Isfahan and the country’s Arak heavy water reactor southwest of the capital.

Rising reported from Dubai, United Arab Emirates. Associated Press writers Mehmet Guzel in Istanbul; Josef Federman in Jerusalem; Samy Magdy in Cairo; Matthew Lee in Washington, D.C.; and Farnoush Amiri and Jon Gambrell in Dubai contributed to this report.